Created for people with ongoing healthcare needs but benefits everyone. Decidualized endometrium is endometrium with changes due to progestins. 8% of all surgical specimens of women with PE. After menstruation, proliferative changes occur during a period of tissue regeneration. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts. Biopsy proliferative phase endometrium with disorder features and focal stromal breakdown. Dr. Pseudoneoplastic glandular response of the female genital tract, first described by Javier Arias-Stella in 1954 as atypical endometrial changes associated with the presence of chorionic tissue ( AMA Arch Pathol 1954;58:112 ) Typically found in the endometria of postabortion curettings of intrauterine or extrauterine pregnancies or with. 2023 Feb 1;141 (2):265-267. There's been a Bank Holiday which usually delays issues. No evidence of endometrium or malignancy. The detection rate for endometrial cancer is approximately 99. The specimen is received. Conclusion One in six postmenopausal women who underwent endometrial sampling had proliferative endometrium. Localized within the uterine wall, extends into the uterine cavity. Thank. Stroma is the connective tissue just below the surface of an organ. Ultrasound(pelvic and trans vaginal) that homogeneous endometrium is seen measuring 5 - 6 mm. Chronic plasmacytic endometritis (CPE) is an infectious or reactive process with multiple etiologies. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. Proliferative activity is relatively common in postmenopausal women ~25%. The uterus is the hollow, pear-shaped pelvic organ where fetal development happens. Early proliferative (day 4-7 ) Straight short glands, thin epithelium. The immunohistochemical staining pattern for CD138 with appr. that is what weakly proliferative endometrium means. ( I have had 5 endometrium biopsies over past 4 years and one D&C 6 years ago) • 01-2021 Endo Biopsy Diagnosis: Pre-hyperplasia, Disordered proliferative endometrium without atypia. It refers to the time during your menstrual cycle when a layer of endometrial cells is prepared for attachment of a fertilized egg. Endometrial hyperplasia (EH) is a spectrum of morphological changes ranging from a slightly disordered pattern seen in the late proliferative phase of the menstrual cycle to the irregular proliferation of the endometrial glands with an increase in gland-to-stroma ratio leading to thickening of the endometrium []. A hysterectomy makes it impossible for you to become pregnant in the future. No polarizing material was present in the granulomas, and. Read More. During. Endometrial carcinoma is the most common invasive neoplasm of the female reproductive tract. At this. What does this test result mean. It is also known as atrophy of the endometrium and endometrial atrophy . -. 3–10% of endometrial biopsies are said to show histologic evidence of chronic endometritis. , from endogenous sources such as obesity or from exogenous. Can be pedunculated or sessile, single or multiple, and up to many centimeters in size. During the menstrual cycle, the endometrium grows under the influence of two major hormones – estrogen and progesterone. 72 mm w/ polyp. -- abundant neutrophils and blood. The term proliferative endometrium refers to the state of the endometrial layer while it grows. Transformation zone not available means that the biopsy was superficial-. Metaplasia is defined as a change of one cell type to another cell type. Endometriosis can reactivate after menopause, particularly if estrogen levels rise again, such as after starting hormone replacement therapy. Absence of uterine bleeding. Pathology report states: postmenapausal weakly-proliferative endometrium with focal glandular crowding. K. If left untreated, disordered proliferative endometrium can change into another non-cancerous condition called endometrial hyperplasia. Your GP probably hadn't had time or knowledge that the report was ready to read. Endometrial epithelial metaplasia refers to the replacement of the normal endometrial glandular epithelium by cells that are either not encountered in the normal endometrium or, if present, are usually inconspicuous elements. DIAGNOSTIC APPROACH. 11. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. Doctor's Assistant: When was your last pap smear? Have you ever had an irregular pap? My pap was good clinical history is abnormal uterine bleeding. 9. Endometrial morphology after 6 months of continuous treatment with a new gonadotropin-releasing hormone superagonist for contraception. The follicular phase of the female menstrual cycle includes the maturation of ovarian follicles to prepare one of them for release during ovulation. Proliferative endometrium(15%) and secretory endometrium (5%) were identified in the postmenopausal women which is a comparable finding to other studies that reported a proliferative endometrium. Initial evaluation — The primary goal in the diagnostic evaluation of postmenopausal patients with uterine bleeding is to exclude. 0001) and had a higher body mass index (33. B. You might want to discuss low dose oral bcp's with your gyn or get a second opinion, as the bcp's stop all. What does weakly proliferative endometrium mean. “The growth, or proliferative, phase of the endometrium happens in the first half of the menstrual cycle prior to ovulation when an ovary releases a mature egg,” explains Dr. The study provides. Pediatrics 35 years experience. This would indicate lack of ovulation. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. 2 percent) Hyperplasia without atypia (2 percent) Hyperplasia with atypia (0. when ovulation doesn't occur the endometrium becomes thick (proliferative), but without the progesterone release of. SCANT SUPERFICIAL FRAGMENTS OF WEAKLY PROLIFERATIVE ENDOMETRIUM, PREDOMINANTLY SURFACE EPITHELIUM. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. Not having a period (pre-menopause)The degree of proliferative activity can usually be assessed by the mitotic activity in both the glandular epithelium and the stroma. Luteal phase defect. Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are benign (ciliated metaplasia) & no precancerous or can. Figure 1. They described functional endometrium as being “weakly proliferative” or “weakly. or weakly proliferative (P=0. Then ovulation occurs. In a review of 518 nonirradiated hysterectomy specimens with endometrial carcinoma and 39 with carcinosarcoma, 86 cases were identified in which there were microscopic foci of malignant epithelium that failed to alter the architecture of an otherwise thin atrophic or weakly proliferative endometrium or endometrial polyp. Tubal metaplasia is a non-cancerous change that involves a group of cells becoming more like the cells that are normally found in the fallopian tube. Microscopic findings. It has a basal layer and a functional layer: the basal layer contains stem cells which regenerate the functional layer. 0000000000005054. Afte. By definition, adenocarcinoma of the endometrium is an invasive disease, invading either the endometrial stroma or the underlying myometrium of extrauterine tissues. this is a description of the uterine lining in response to estrogen. While embryo development and endometrial preparation are concurrent yet independent processes, their synchronization is critical to the success of embryo apposition, adhesion, invasion, and further ongoing. No worries, I know what you mean for sure. The proliferative and hyperplastic endometrium was commonly reported. Of these, 33 (23%) had an outcome diagnosis of EIN (27 cases; 19%) or carcinoma (6 cases; 4%). 2023 Feb 1;141 (2):265-267. The endometrium is a complex tissue that cyclically regenerates every menstrual cycle in preparation for embryo implantation. Endometriosis is a condition in which cells similar to the lining of the uterus, or endometrium, grow outside the uterus. 1, 2 They are the second most common uterine mesenchymal tumor after leiomyosarcoma. Proliferate definition: . 2 percent) By comparison, the background prevalence of endometrial pathology in postmenopausal patients without bleeding is lower. Post-menopausal bleeding (PMB) is usually caused by several endometrial conditions (hyperplasia and carcinoma) for which there are evidence-based treatments. What is it? Symptoms Complications Treatment Summary Disordered proliferative endometrium can cause spotting between periods. Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. This condition is detected through endometrial biopsy. 02 - other international versions of ICD-10 N85. when they faced with a series of two endometrial biopsies and a subsequent hysterectomy specimen of a young woman with menorrhagia. It aims to clarify the diagnostic criteria and differential diagnosis of these lesions, as well as their possible association with endometrioid neoplasia. Endometrial Stromal Nodule (ESN) and Low-Grade Endometrial Stromal Sarcoma (LG-ESS) ESN is a benign, whereas LG-ESS is a malignant neoplasm of the uterus (affecting the body of the uterus more than the cervix) and extra-uterine sites [8,9]. is this something t?. Weakly proliferative endometrium does not denote a specific functional state but is better conceptualized as a morphologic pattern. My pathology report final diagnosis are as follows: Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. Glands. This is healthy reproductive cell activity. Pearson x2, Fisher and Wilcoxon tests were used for statistical analysis as appropriate. Applicable To. Painful intercourse (dyspareunia) Your uterus might get bigger. Can be pedunculated or sessile, single or multiple, and up to many centimeters in size. Frequent, unpredictable periods whose lengths and heaviness vary. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. Unremarkable squamous epithelium is also normal and mucus is a normal finding. Need to see whole: report for a meaningful interpretation. Created for people with ongoing healthcare needs but benefits everyone. The main purpose of the endometrium is to provide an attachment site and a source of nourishment to an early embryo. Adenofibromas most commonly occur in postmenopausal women but the age range is wide. Note that when research or. Deborah Josefson: Excess estrogen : This is suggestive of an increased estrogen state an. While embryo development and endometrial preparation are concurrent yet independent processes, their synchronization is critical to the success of embryo apposition, adhesion, invasion, and further ongoing. In one study, follow-up outcomes of "gland-crowding" reports show 77% benign lesions (proliferative endometrium, secretory endometrium, endometrial polyp, etc. Created for people with ongoing healthcare needs but. 7. Proliferative is first part of cycle, dominated by estrogen. Before treatment, 56 subjects (60%) had an endometrial biopsy with findings classified as weakly proliferative or proliferative. Fragments of benign leiomyoma. •ICCR definition:-REQUIRED ELEMENTS- those which are unanimously agreed by the panel to be essential for the histological diagnosis, clinical. New blood vessels develop and the endometrial glands become bigger in size. Dr. 0001). 8% of all surgical specimens of women with PE. 02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. A secondary goal is to exclude other intraabdominal processes (eg, diverticular disease,. 8 is applicable to female patients. 9 vs 30. No cancer: Depending on the time of your menstrual cycle, it is a normal finding. 8 may differ. The pathologist must be aware of the spectrum of endometrial metaplasias encountered and the clinical setting in which they. The term “proliferative” means. 0001). 0 x 0. Dr. Adenomyosis is distinct from endometriosis, which is the presence of endometrial. « lining in uterus thickened | Cells from uterus that show up in a pap ». The uterus is a muscular, pear-shaped, hollow organ that forms an important part of the. 9% Secretory Endometrium 151 14. •ICCR definition:-REQUIRED ELEMENTS- those which are unanimously agreed by the panel to be essential for the histological diagnosis, clinical. Read More. Characteristics. : FRAGMENTS OF BENIGN ENDOCERVICAL POLYP. I was diagnosed with disordered proliferative endometrium with glandular and stromal breakdown, benign polyps simple hyperplasia w/o atypia, a fibroid size of grapefruit pressing on bladder. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. The findings in endometrial biopsies taken for abnormal uterine bleeding can show a wide range of appearances that reflect the cyclical changes in the endometrium in women during their reproductive years; accordingly, the histopathological diagnosis provides a description of the features observed microscopically (e. This pictorial review takes you through the hysteroscopic view of normal-looking. This pictorial review takes you through the hysteroscopic view of normal-looking. Proliferative endometrium isn’t a symptom or condition. Wendy Askew answered. • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. Ed Friedlander and 4 doctors agree. Best would be to contact the pathologist who wrote the report. Pathology 51 years experience. Most women (90%) with endometrial cancer develop symptomatic vaginal bleeding or discharge, and this is often what prompts them to seek gynecologic care. 0001). The Proliferative Phase. stroma. X. 2; median, 2. Hormone replacement therapy with estrogen alone may result in continuous endometrial proliferation, hyperplasia, and neoplasia. The 2024 edition of ICD-10-CM N85. Adenofibromas most commonly occur in postmenopausal women, but the age range is wide. SEE COMMENT. There were some proliferative endometria with cystically dilated glands that were indistinguishable from a disordered proliferative, or anovulatory, endometrium. I am postmenopausal with uterine bleeding. during your monthly. After menstruation, proliferative changes occur during a period of tissue regeneration. Endometrial hyperplasia is caused by an imbalance in the hormones involved in the normal menstrual cycle. The lesion is reportedly often associated with pelvic inflammatory disease and intermenstrual bleeding. For example, the endometrium in most term foetuses and neonates is only weakly proliferative, despite prolonged exposure to very high concentrations of unbound estrogens and progesterone in utero. Endometrium - EMC - Fragments of weakly proliferative/inactive endometrium. This is the microscopic appearance of normal proliferative endometrium in the menstrual cycle. 3–10% of endometrial biopsies are said to show histologic evidence of chronic endometritis. What does disordered proliferative endometrium mean? Disordered proliferative endometrium is a non-cancerous change that develops in the endometrium, a thin layer of tissue that lines the inside of the uterus. These can lead to abnormal bleeding. It is further classified. is this something t? Dr. "pathology report states: postmenapausal weakly-proliferative endometrium with focal glandular crowding. However, certain conditions can develop if the. Cystically dilated glands (> 2x normal size) randomly interspersed among proliferative endometrial glands. 5 to 7–8 mm during the mid-proliferative phase ( 17 ). X. What does this mean? waiting to hear from doctor. Proliferative endometrium describes the 'stage' of the endometrium when it was biopsied. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. 00 - other international versions of ICD-10 N85. Biopsy was done because I had a day of spotting 17 months. Atrophic endometrial tissue is smaller than normal endometrial tissue and has lost some of its function. 5% of women with abnormal uterine bleeding had proliferative or secretory endometrium. The proliferative endometrium is what is shed from the uterus when a woman has her cycle. Proliferative endometrium suggests active estradiol secretion, akin to that seen in the proliferative phase of the menstrual cycle, and is not a form of EH. Definition/Introduction. Main. Family Medicine 49 years experience. Some, but not all features of atrophy may also be seen in. The Proliferative Phase. 5), with loss of distinction between the basal and functional layer; (b) proliferative type endometrial glands, somewhat tortuous, with tall. We have described the dynamics of the pattern of growth of. Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferative Endometrial hyperplasia Asynchronously developed endometrium. The first half of the proliferative phase starts around day 6 to 14 of a person’s cycle, or the time between the end of one menstrual cycle, when bleeding stops, and before ovulation. and 200 cases of endometrial samples with typical tubal metaplasia were followed for a mean of 64 and 61 months, respectively. Serous carcinoma is the prototypic endometrial carcinoma that is not related to estrogenic stimulation and typically occurs in the setting of endometrial atrophy. Therefore, it is necessary to know the phase of the menstrual cycle and the endometrial biopsy volume to. Looking for help on a biospy report: weakly proliferative. Fibroids (benign uterine muscle growths) and polyps (endometrial masses) often cause no symptoms. These symptoms can be uncomfortable and disruptive. Deborah. Learn how we can help. Frequently, in histological samples of EGBD, metaplastic changes occur also in the endometrial surface epithelium (Figs. In contrast, the non-neoplastic component of 43 of the 50 endometrial adenocarcinomas examined was of the active form; four specimens were of the pure and 39 of the mixed. The stromal cells are arranged in a compact manner. Acute endometritis can happen after childbirth or miscarriage, or after a surgical procedure involving your cervix or uterus. The significance of the findings is that the metaplasia may present an. 2; median, 2. The unstained glands are irregularly dispersed with focal back-to-back crowding. Normal: Your endometrial lining was in the proliferative phase of the menstrual cycle. 3,246 satisfied customers. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. Hysteroscopy is now considered the standard diagnostic tool. In this study we correlate the # of plasma cells by H&E to the # of plasma cells by CD138 IHC in endometrial biopsies. 12. 72 mm w/ polyp. Conclusions Weakly proliferative endometrium suggests there has still been a little estrogen present to stimulate the endometrium, whether from your ovaries, adrenals, or from conversion in fat cells. 3k views Reviewed >2 years ago. 04, 95% CI 2. An endometrial polyp was found in 86. I had a biopsy with a d and c 15 weeks ago that was returned benign, negative for hyperplasia and carcinoma. Prognosis. The inactive endometrium was atrophic either under physiological condition or under GnRH-antagonist treatment. Compact. Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. [10]: (1) constant appearance of basalis throughout the menstrual cycle, (2) glands of the basalis appear weakly proliferative, (3) basalis cells lack secretory features and the stroma is spindled. ICD-10-CM Coding Rules. These sound like the results from an endometrial biopsy - basically, when your doctor takes a clipping or scraping from inside the uterus and sends it off to a pathologist to be examined. What does a weakly proliferative endometrium mean? It is probable that the presence of a weak proliferative pattern in a postmenopausal atrophic endometrium is a response of the uterine mucosa to continuous low level oestrogenic. Endometrioid. Proliferative endometrium is a very common non-cancerous change that develops in the tissue lining the inside of the uterus. does scant superficial strips of inactive endometrium seperate fragments of unremarkable squamous epithelium & mucus mean on an endometrial biops? 1 doctor answer • 2 doctors. g. 2. It has a basal layer and a functional layer: the basal layer contains stem cells which regenerate the functional layer. Ultrasound Results mild endometrial thickening 7-8 mm. The likelihood that women initially found to have proliferative changes were subsequently diagnosed with endometrial hyperplasia or cancer was almost 12%, some. 0 x 3. 2; median, 2. 9 and 12. 6k views Reviewed Dec 27, 2022. An introduction to the endometrium is found in the endometrium article. 0001). Be sure to rule out a neoplastic process (endometrial hyperplasia or carcinoma) Stromal metaplasias (while uncommon) include osseous, cartilaginous, myomatous, adipose and synovial-like. Definition focal overgrowth of localized benign endometrial tissue. Fibrosis of uterus NOS. 2 vs 64. DDx. 5. Re: Disordered Proliferative Endometrium. Van den Bosch et al 11 found that 14. Definition A proliferative endometrium is a normal part of healthy. How is proliferative endometrium treated? Endometrial hyperplasia treatment The most. 2 vs 64. Contrary to endometrial hyperplasia, proliferative endometrium has not been associated with the risk of endometrial cancer. Endometrial Polyp B. This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. Answer. A hysterectomy stops symptoms and eliminates cancer risk. 0–3. Learn how we can help. If you stopped the Prempro, the buildup would disappear, and the bleeding would go away. A proliferative endometrium is a normal part of healthy uterine function when it occurs during the first half of the menstrual cycle. This refers to: Build up of the uterine lining, as would happen in the cycle prior to ovulation (egg release) to prepare for implantation of the fertilized egg. The ratio of glands to stroma increases compared to the normal proliferative phase endometrium, exceeding the ratio of 3:1 in hyperplasia. 0001) and had a higher body mass index (33. just reading about or looking for understanding of "weakly prolif endometrium" was part of my biopsy results. EMCs. Proliferative endometrium is part of the female reproductive process. Results: After intervention in letrozole group, response to treatment was seen in 93% cases (including endometrial atrophy in 58. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. 1. It can be healthy or disordered depending on the rate of cell growth and shedding. Uterine polyp and endometrial polyp redirect here. Introduction. Introduction. 62% of our cases with the highest incidence in 40-49 years age group. - Negative for polyp, hyperplasia, atypia or. Read More. Metaplasia in Endometrium is diagnosed by a pathologist on. 11. stroma. 00 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. cally, the endometrium may show a spectrum of change ranging from total atrophy (basalis layer only) to a weakly proliferative endometrium with occasional mitotic figures and a thin functionalis layer. Endometriosis can affect women of any age, including teenagers. Glands. Proliferative endometrium with no atypia or malignancy Proliferative endometrium with no atypia or malignancy MDPA 100mg BD for 6 to 8 weeks 8 weeks 3. EH, especially EH with atypia, is of clinical significance because it may progress to. Microscopic findings. Dr. The endometrium is normal proliferative phase in which buds of small morules were scattered (Figure 1C). Furthermore, 962 women met the inclusion criteria. Signs and symptoms of uterine polyps include: Vaginal bleeding after menopause. Fibroids (benign uterine muscle growths) and polyps (endometrial masses) often cause no symptoms. This pattern may be seen in the perimenopausal years, or in postmenopausal years if there is a source of at least low-level estrogenic stimulation (e. Sometimes, adenomyosis causes no signs or symptoms or only mild discomfort. Hormonal imbalances: Hormonal imbalances, such as decreased levels of estrogen and progesterone, can contribute to the endometrium. 1646 postmenopausal women aged 55-96 (mean 64. resembling proliferative phase endometrium. Inactive endometrium is normal in post menopausal women. Compact. If left untreated, disordered proliferative endometrium can change into another non-cancerous condition called. Gurmukh Singh answered. A menstrual cycle for one woman may last for a few days but for another woman may last a. The degree of proliferation can vary in proportion to the estrogenic stimulus. A "d&c" which is reported as "scant glandular endometrium " is a benign pathological condition. 0% Exogenous. -- abundant neutrophils and blood. (tend to diagnose disordered proliferative endometrium in perimenopausal years) •occasional dilated glands with proliferative activity, stromal breakdown, metaplasias (especially ciliated). Endometrial hyperplasia is a condition of the female reproductive system. "Exodus" pattern is a term used to describe exfoliation of endometrial cells during the proliferative phase. Exogenous hormones taken for various reasons may have an effect on the morphology of endometrium, endometrial stroma and myometrial lesions, such as leiomyomas. Endometrial hyperplasia is a disordered proliferation of endometrial glands. Interestingly, presence of polyp tissue was associated with endometrial cancer outcome in both the unadjusted (univariate) and adjusted (multivariable) models (OR 4. 02 may differ. This may explain the development of endometrial adenocarcinoma in. 9 and 12. This book chapter provides an overview of the epidemiology, risk factors, diagnosis, staging, and treatment of endometrial cancer, as well as the latest research and guidelines. 5%. Proliferative Endometrium in Menopause: To Treat or Not to Treat? Obstet Gynecol. Early detection and accurate diagnosis of these lesions and its precursor by endometrial cytology is now accepted in Japan and regarded as an effective primary method of evaluating endometrial pathology (atypical hyperplasia or carcinoma. Doctoral Degree. 2. 25% of patients with endometrial cancer had a previous benign EMB/D&C. It is also seen in exogenous estrogen therapy and is a result of dys-synchronous growth of the. 3%) 'gland crowding' cases were identified, in which 69% (143/206) had follow-up sampling. The risk. A nonneoplastic lesion of myometrial tissue characterized by the presence of endometrial glands and stroma within myometrium. Endometrial polyps are common and usually benign. 9 vs 30. focal mucinous metaplasia. No apparent endometrial hyperplasia was seen. The metaplasia doesn't mean anything significant, and the glandular and stromal breakdown is often seen when there has been bleeding. In the past, the terms “adenomatous hyperplasia” and “atypical hyperplasia” were used to denote proliferative lesions of the endometrium with varying degrees of architectural complexity and cytologic atypia [15, 32, 37, 70, 93]. Methods. read moreEndometrial Hyperplasia; An Update on Human Papillomavirus Vaccination in the United States; Effect of Second-Stage Pushing Timing on Postpartum Pelvic Floor Morbidity: A Randomized Controlled Trial; Permanent Compared With Absorbable Suture in Apical Prolapse Surgery: A Systematic Review and Meta-analysisUterine corpus cancer is the most prevalent gynecologic malignancy in American women with over 60,000 new cases expected during the next year and accounting for nearly 11,000 deaths. Women with a proliferative endometrium were younger (61. I had a biopsy with a d and c 15 weeks ago that was returned. More African American women had a. the mean age, weight, FSH and oestradiol. endometrial intraepithelial neoplasia (EIN). Hysteroscopy combined with biopsy increases the accuracy of diagnosis up to 100%. The endometrium is the mucous membrane that is found lining the inside of the uterus, and the term ‘Disordered Proliferative Endometrium’ is used to describe a hyperplastic appearance of the endometrium without an increase in the endometrial volume. Endometrial hyperplasia (EH) is a pre-cancerous, non-physiological, non-invasive proliferation of the endometrium that results in increased volume of endometrial tissue with alterations of glandular architecture (shape and size) and endometrial gland to stroma ratio of greater than 1:1 [5,6]. 5 cm. 0000000000005054. Learn how we can help. Women who are many years postmenopausal demonstrate profound endometrial atrophy, secondary to lack of estrogen, but even atrophic endometrium remains estrogen responsive to quite advanced age.