proliferative endometrium icd. 00 - Endometrial hyperplasia, unspecified. proliferative endometrium icd

 
00 - Endometrial hyperplasia, unspecifiedproliferative endometrium icd 5 years; P<

The uterus does this to create a place where a potential fertilized egg can implant and grow (10). 2 became effective on October 1, 2023. This is the American ICD-10-CM version of N85. 89 [convert to ICD-9-CM] Other postprocedural complications and disorders of eye and adnexa, not elsewhere classified. N83. The specific ICD-10 code will depend on the type and severity of the condition. There is risk of premalignant lesions in patients diagnosed with AGC is as high as 11%, the risk of endometrial cancer is 3%, and the risk of cervical cancer is 1%. N85. 01 became effective on October 1, 2023. In 47 cases (80%), there was a coexisting endometrial polyp, 39 (66%) of which were involved by the PPE. Learn how we can help. Define proliferative endometrium. endometrial hyperplasia is classified by its cytology and glandular tissue. 5. Not having a period (pre-menopause)Atrophic, inactive, proliferative, early secretory, late secretory, and hyperplasic endometria have been reported in HT users of different regimens. Hyperplasia was observed in 25 patients (Graph 1) of which 8 patients presented with atypia (Fig. Sometimes, adenomyosis causes no signs or symptoms or only mild discomfort. the acceptable range of endometrial thickness is less well. 6k views Reviewed Dec 27, 2022. 30 - other international versions of ICD-10 N80. 10170. This is the American ICD-10-CM version of N84. Benign endometrial hyperplasia Billable Code. Fig. Created for people with ongoing healthcare needs but benefits everyone. Endometrial hyperplasia without atypia (as in the 2020 WHO classification) is defined as the proliferation of endometrial glands of irregular size and shape without significant cytological atypia. N85. This is the American ICD-10-CM version of N85. 1 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The following code (s) above N85. In two cases, endometrial papillary proliferation was observed in the specimens from endometrial curettage procedures that had been performed to evaluate postmenopausal vaginal bleeding and thickened endometrium; in both of these cases, subsequent endometrial hyperplasia was observed during follow-up and hysterectomy. An absence of proliferative and mitotic activity distinguishes it from proliferative endometrium. 90% of endometrial bxs by CD138. The 2024 edition of ICD-10-CM N71. DDx: Endometrial hyperplasia with secretory changes. This is the American ICD-10-CM version of D72. 328 results found. Thank. Women of EC and hyperplasia group were more likely to be multiparous, diabetic, hypertensive, obese or. adenomatous polyp ( D28. ↓ See below for any exclusions,. ICD-O: 8931/3 - endometrial stromal sarcoma, low grade ICD-11: 2B5C & XH1S94 - endometrial. N84. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. 01 is a billable ICD code used to specify a diagnosis of benign endometrial hyperplasia. Barrett's esophagus with high grade dysplasia. ICD-10-CM Coding Rules. Abstract. (lower than in proliferative phase. In the epithelioid regions small inactive glands with an immunofenotype different from the remaining endometrium might be observed. Fifty-three cases (90%) had coexisting epithelial metaplastic changes, 41 (77%) of which were involved by the PPE. N85. 10. Lindemann adds that treatment of the condition in a premenopausal. When it does occur it is a cause of concern as it is associated with lower implantation rate and pregnancy rate. 01. ICD-10-CM Codes. 04 became effective on October 1, 2022. Abnormal discharge from the vagina. 00 is a billable diagnosis code used to specify a medical diagnosis of endometrial hyperplasia, unspecified. 01. Previous Code: N87. Metaplasia in Endometrium is a common benign condition that occurs in the glands of the endometrial lining (of the uterus). Most useful feature to differentiate ECE and SPE is the accompanying stroma. doi: 10. This is the American ICD-10-CM version of K22. Represents the most common form and is characterized by glandular proliferation, with variable shape and size, bordered by proliferative epithelium with mitotic activity; the interglandular stroma can be reduced, the differentiation from endometrial hyperplasia being made on account of the vessels with. The significance of the findings is that the metaplasia may present. 01 - Benign endometrial hyperplasia. Read More. Postmenopausal,. Endometriosis fallopian tube NOS. DISORDERED PROLIFERATIVE ENDOMETRIUM (anovulatory) •common, especially in perimenopausal years •response to increased oestrogenic drive without opposition of progestogen, usually secondary to anovulatory cycles •merges with simple hyperplasia (part of same spectrum) (tend to diagnose disordered proliferative endometrium in. N80. 0001). More African American women had a proliferative. Dr. 30 became effective on October 1, 2023. 2 : N00-N99. ICD-10 codes related to endometrial hyperplasia –. The majority of endometrial cancer cases are detected and diagnosed in women aged 50 years and older; The following link can help you understand. Share. 9 became effective on October 1, 2023. LM. Endometrium: Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferativeDisordered proliferative Endometrial hyperplasia Asynchronously developed endometrium Persistent Proliferative Dilated proliferativeDilated proliferative type glands, with pseudostratification Focal breakdown common Due to unopposed estrogen In evaluating an endometrial biopsy specimen, an adequate clinical history is important, including the age of the patient and the reason for the biopsy. 02. 1038/modpathol. 00. This is the American ICD-10-CM version of N85. 8 – other international versions of ICD-10 N85. 30 - other international versions of ICD-10 O34. This is the American ICD-10-CM version of Z86. There were some proliferative endometria with cystically dilated glands that were indistinguishable from a disordered proliferative, or anovulatory, endometrium. In ICD-O-3, sub sites within the body of the uterus have been assigned separate codes at the decimal level. atrophy, endometrial hyperplasia, endometrial carcinoma, other gynecologic cancers. Periovulatory, 10 ± 1 mm. Endometrial cancer with myometrial invasion;. A condition in which multiple fibromas develop. If the biopsy was done in the first half of the cycle, the endometrium is expected to be in proliferative phase. The menopausal status as well as the date of onset of the last menstrual period and the length of the menstrual cycle in premenopausal women should be provided. Benign endometrial hyperplasia Billable Code. 11. The 2024 edition of ICD-10-CM D17. ICD-10-CM N71. The two most accepted mechanisms involve either the presence of chronic. 9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Follow-up information was known for 46 patients (78%). 2 vs 64. Postmenopausal bleeding. Learn how we can help. Proliferative endometrium (29/77, 37. 8 - other international. 02 is a billable diagnosis code used to specify endometrial intraepithelial neoplasia [ein]. 0001). 711 may differ. The pathogenesis and natural history of endometrial polyps are not very clear, 10 exact cause of endometrial polyps is unknown, however, there are several theories proposed relating to the aetiology and pathogenesis of these lesions. Sessile polyps can be confused by submucous fibroids. Showing 1-25: ICD-10-CM Diagnosis Code N84. Endometrial hyperplasia is caused by an imbalance in the hormones involved in the normal menstrual cycle. N85. Atrophic endometrial tissue is smaller than normal endometrial tissue and has lost some of its function. Furthermore, 962 women met the inclusion criteria. Cytoplasmic vacuoles become supranuclear, and secretions are seen within the glandular lumina (Fig. 8%), endometrium hyperplasia (11. The presence of CD138+ plasma cells may not equate to chronic endometritis. 2 vs 64. O34. 2 would be correct as an additional diagnosis, but not the primary diagnosis - that is, the reason the procedure was being performed. With a threshold of 5 mm for ET, the sensitivity for detecting any endometrial disease was 92%, and the sensitivity for detecting EC was 96%. Introduction. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. TYSON1234 Guru. The 2024 edition of ICD-10-CM M72. 298 results found. Showing 1-25: ICD-10-CM Diagnosis Code N84. SPE - eosinophilic cytoplasm. The histologic types of glandular cells are columnar or cuboid. The 2024 edition of ICD-10-CM N80. The polyp attaches to the endometrium by a thin stalk or a broad base and extends into your uterus. Endometriosis of rectovaginal septum, unsp invl of vagina; Endometriosis of the rectovaginal septum, NOS. Furthermore, 962 women met the inclusion criteria. However, they can cause other symptoms as they grow and compress the surrounding organs, like the bladder or bowel. 02 became effective on. Normal: After menstruation is over the lining of the endometrium begins to proliferate and grow. Z codes represent reasons for encounters. Adenocarcinoma of endometrium; Cancer of the endometrium; Cancer of the endometrium, adenocarcinoma; Cancer of the endometrium, adenosquamous; Cancer of the endometrium, clear cell;. This code is applicable to female patients only. 3522. 1 of the Program Integrity Manual. As a result of involution of the ovaries, falling sex hormones mark the end of the reproductive phase. 8 - other international versions of ICD-10 N84. ICD-10-CM Diagnosis Code N80. Often it is not even mentioned because it is common. The 2024 edition of ICD-10-CM E28 became effective on October 1, 2023. The following code(s) above D17. Early proliferative (day 4-7 ) Straight short glands, thin epithelium. Compact. 34 should only be used for claims with a date of service on or before September 30, 2015. satisfied customers. ; The 2024 edition of ICD-10-CM N80. 8 is a billable diagnosis code used to specify a medical diagnosis of other specified noninflammatory disorders of uterus. 3 Nephrotic syndrome with diffuse mesangial proliferative glomerulonephritisLow grade endometrial stromal sarcoma is a malignant mesenchymal tumor comprising cells resembling proliferative phase endometrial stroma with infiltrative growth or lymphovascular invasion. 04 - genetic susceptibility to malignant neoplasm of endometrium. endometrial thickness in the secretory phase (days 14-28) may normally be up to 12-16 mm (see: endometrial thickness) non-emergent ultrasounds are optimally evaluated at day 5-10 of the menstrual cycle to reduce the wide variation in endometrial thickness. General Surgeon. The lining of the uterus (endometrium) becomes unusually thick because of having too many cells (hyperplasia). Endometriosis and adenomyosis are two frequent diseases closely linked, characterized by ectopic endometrium. What does endocervical mean? The inner part of the cervix that forms a canal that connects the vagina to the uterus. Endometrial metaplasia can be associated with hyperestrogenism, inflammation, repeated irritation or endometrial polyps. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. . 70 became effective on October 1, 2023. This finding suggests that miR-29c may influence endometrial genes associated with cell cycle progression and. 4. The main purpose of the endometrium is to provide an attachment site and a source of nourishment to an early embryo. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. 0% (95% CI 2. A 'billable code' is detailed enough to be used to specify a medical diagnosis. Created for people with ongoing healthcare needs but benefits everyone. 00. 2 - other international versions of ICD-10 N80. Can you explain what stromal and glandular breakdown is and if that is significant finding in a postmenopausal 58 year old woman. In fact, in 2018, the ACOG committee opinion stated that "Postmenopausal vaginal bleeding usually is caused by atrophic changes of the vagina or endometrium" [ 3 ]. 1. Endometrial hyperplasia is a condition of excessive proliferation of the cells of the endometrium, or inner lining of the uterus. Spectrum of common pathologies that can be detected histologically in AUB include hormonal imbalance pattern (disorderly proliferative endometrium, non secretory endometrium with stromal and glandular breakdown, luteal phase defect and pill effect) atrophic endometrium, endometritis, endometrial polyp, endometrial hyperplasia and. Menstrual bleeding between periods. ajog. Benign neoplastic lesions were observed in 27 patients; 27 had benign polyps and one case of leiomyoma upon D&C was confirmed to be a benign polyp. “The growth, or proliferative, phase of. 1992 Aug;37 (8):685-90. 8 may differ. Use Additional. The uterus does this to create a place where a potential fertilized egg can implant and grow (10). The ratio of glands to stroma increases compared to the normal proliferative phase endometrium, exceeding the ratio of 3:1 in. Risk factors for developing endometrial cancer after benign endometrial sampling. Arias-Stella is a reactive phenomenon of the endometrium induced by high dose estrogen / progesterone in the setting of pregnancy, gestational trophoblastic disease or secondary to hormone therapy. , 1985). N80. The most common type of metaplasia was mucinous (41 of 59 cases, or 69%). 711 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. 8 [convert to ICD-9-CM] Other specified noninflammatory disorders of uterus. Symptoms. INTRODUCTION. Oth diabetes w prolif diabetic retinopathy w macular edema; Proliferative retinopathy with macular edema due to secondary diabetes mellitus; Secondary diabetes with macular edema. Women with a proliferative endometrium were younger (61. Irregular menstruation. In each menstrual cycle, the endometrium becomes receptive to embryo implantation while preparing for tissue breakdown and repair. 01 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Search Results. Applicable To. The endometrium is a complex and dynamic multicellular tissue that responds to the ovarian hormones. This is the American ICD-10-CM version of M72. N85. N85. I had the surgery as it was highly encouraged by the gyn/onc surgeon. 3539 [convert to ICD-9-CM] This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. Obstetrics and Gynecology 29 years experience. [1] This imbalance in the hormonal milieu can be seen in a number of conditions where the cause of estrogen excess is either endogenous or exogenous. 89. Treatment. Contrary to endometrial hyperplasia, proliferative endometrium has not been associated with the risk of endometrial cancer. The stromal cells are arranged in a compact manner. 3%). The cells are checked under a microscope for infection, inflammation, and cancer or changes that may become. 82 lookup. 0. 00 for Endometrial hyperplasia, unspecified is a medical classification as listed by WHO under the range - Diseases of the genitourinary system . Moderate estrogen effect. Code History. Common reasons for these procedures include: Abnormal (dysfunctional) uterine bleeding. Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with traction retinal detachment involving the macula, left eye. During a pelvic exam, cells may be scraped from the endocervix. This condition is detected through. 9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Torres ML, Weaver AL, Kumar S, et al. doi: 10. N71 should not be used for reimbursement purposes as there are multiple codes below it that contain a greater level of detail. Among the 536 in the nulliparous group, the predominant pattern noted was the functional endometrium pattern (n=361, 67. So during the menstrual cycle, or period, this tissue responds to. Z30. 743 Uterine and adnexa procedures for non-malignancy without cc/mcc. endometrial thickness in the secretory phase (days 14-28) may normally be up to 12-16 mm (see: endometrial thickness) non-emergent ultrasounds are optimally evaluated at day 5-10 of the menstrual cycle to reduce the wide variation in endometrial thickness. Both pregnancy and menstruation are dependent on spontaneous decidualization of endometrial stromal cells, a progesterone-dependent process that follows rapid, oestrogen-dependent proliferation. The difficulty with mucinous metaplasia lies in its. ICD-10-CM Diagnosis Code N80. 03 became effective on October 1, 2023. 9 - other international versions of ICD-10 N85. Typical trilaminar appearance of the endometrium in the proliferative phase of the menstrual cycle. To evaluate the heterogeneity and dynamic evolution characteristics of decidualized stromal cells, we analyzed the expression of marker molecules of decidualization in human endometrium during proliferative and secretory phases, and decidualized. Gudmundsson JA, Lundkvist O, Bergquist C, Lindgren A, Nillius SJFertil Steril 1987 Jul;48 (1):52-6. As well as being misplaced in patients with this condition, endometrial tissue is completely functional. ICD-10-CM Coding Rules. exocervix N80. N84. During the menstrual cycle, the endometrium grows under the influence of two major hormones –. Plasma cells were rare in inactive endometrium and noted in only 18% of unremarkable proliferative endometrium, all grade 1. The 95 areas consisted of 39 benign nonhyperplastic endometria (including four normal proliferative phase, four normal secretory phase, seven abnormally cycling endometria, five atrophic. Abnormal uterine bleeding associated with ovulatory dysfunction (AUB-O) or anovulatory bleeding, is non-cyclic uterine bleeding characterized by irregular, prolonged, and often heavy menstruation. 8 may differ. On 10/28/21 she underwent colposcopy. The average age of menopause is 51 years, but this can vary between 45 and 55 years and, in extreme cases, may be as early as 30s to as late as 60s. Am J Obstet Gynecol 2003; 188:401. N85. 02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Currently, the incidence of EH is indistinctly reported. 1–1. Endometrial hyperplasia is a condition of excessive proliferation of the cells of the endometrium, or inner lining of the uterus. Treatment of endometrial hyperplasia with the insertion of a hormone-containing intrauterine device (IUD) is an accepted method to manage endometrial hyperplasia for patients with abnormal uterine bleeding and who are unable to tolerate oral megestrol or are at high risk for complications of oral megestrol. Endometrial hyperplasia is an abnormal proliferative response to estrogenic stimulation. 10/31/2019 R5 This article is being revised in order to adhere to CMS requirements per chapter 13, section 13. In this phase, tubular glands with columnar cells and surrounding dense stroma are proliferating to build up the endometrium following shedding with previous. 5%) endometrium (Fertil Steril 2021;115:1312, Int J Gynecol Pathol 2019;38:520) Focal stromal decidual-like changes Transitional cell metaplasia of ectocervical and transformation zone epithelium or cervical atrophy ( Obstet Gynecol 2021;138:51 )Office hysteroscopy during the proliferative phase indicated that the suspicious endometrial cancerous lesion was minimal at the isthmus of the uterus with atypical vessels and a white spot, for which biopsy was performed. 22 contain annotation back-referencesThe endometrium is the lining of the uterus. During the menstrual cycle, the endometrium grows under the influence of two major hormones – estrogen and progesterone. -) May be day 5-13 - if the menstruation is not included. There were no overtly premalignant. 3%) 'gland crowding' cases were identified, in which 69% (143/206) had follow-up sampling. 01) N85. 5 - 40%) or secretory (4 - 7. N85. Endometrial hyperplasia is a condition of the female reproductive system. Typical trilaminar appearance of the endometrium in the proliferative phase of the menstrual cycle. Endometrial changes of oral contraception, oral contraceptive effect, OCP endometrium, and endometrium with hormonal changes redirect here. The tissue thickens, sheds. 89; Congestion, congestive. Because the endometrial glands and stroma gradually undergo the process of squamous metaplasia, in a scanty biopsy material the picture may lead to overdiagnosis. Proliferative endometrium 46371004. Showing 1-25: ICD-10-CM Diagnosis Code C54. 2023 - New Code 2024 Billable/Specific Code Female Dx. It is also simply known as endometrial polyp which is a somewhat ambiguous descriptor as not all endometrial polyps are benign. Epithelium (endometrial glands) 2. The 2024 edition of ICD-10-CM Z86. The code is valid during the fiscal year 2023 from October 01, 2022 through September 30, 2023 for the submission of HIPAA-covered transactions. This is the American ICD-10-CM version of O86. The endometrium is the hormonally responsive glandular tissue lining the uterine cavity. Cystically dilated glands (> 2x normal size) randomly interspersed among proliferative endometrial glands. 0001) and had a higher body mass index (33. Endometrium with hormonal changes. Genetic susceptibility to malignant neoplasm of endometrium. Relatively normal gland to stroma ratio (glands occupy < 50% of the surface area. The uterus is the hollow, pear-shaped pelvic organ where fetal development happens. Stroma (endometrial stroma) The structure and activity of a functional endometrium reflect the pattern of ovarian hormone secretion. Disordered proliferative endometrium is common in the perimenopausal years because of anovulatory cycles. 822 became effective on October 1, 2023. This is the American ICD-10-CM version of N85. Every month, this lining builds and thickens in preparation for a potential pregnancy, providing the ideal environment for the implantation of a fertilized egg. Atrophic endometrium (AE) has always been considered a crucial cause of PMB, with ranges between 30 and 50% [ 6, 7, 8 ]. [1] It represents one of the identified causes of abnormal uterine bleeding (AUB), a frequently encountered chief complaint in the primary care. Epithelium (endometrial glands) 2. For AH/EIN and normal control endometria, unstained 4 μm sections were cut from one representative tissue block for each case. O86. A 59-year-old woman with a BMI of 32 and who does not use menopausal hormones presents with uterine bleeding. 6 may differ. Characteristics. 1 million visits to. This is the American ICD-10-CM version of N85. Under ICD-10 Codes that Support Medical Necessity Group 1: Codes added N84. Question: An old issue of the Ob-gyn Coding Alert has an example of CPT ® 58100-endometrial sampling (biopsy) as: ". My uterine biopsy is as follows: benign endometrium with stromal and glandular breakdown. 3%) 'gland crowding' cases were identified, in which 69% (143/206) had follow-up sampling. 9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Learn how we can help. Z86. Proliferative endometrium 46371004. N71. 5. During the follicular or proliferative phase, estrogen signals for the cells lining the endometrium to multiply and for blood vessels to grow to supply the new layers of cells. Gender: Female. 430 may differ. This is the American ICD-10-CM version of N84. During the menstrual cycle, the endometrium grows under the influence of two major hormones –. Possible symptoms of cervicitis include bleeding between menstrual periods, pain with intercourse or during a pelvic exam, and abnormal vaginal discharge. 441 results found. 441 results found. 3539 [convert to ICD-9-CM]This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. 2%), and endometrial polyp (5. : endometrial hyperplasia with atypia and endometrial hyperplasia without atypia. Adapted from Horne et al. A condition in which multiple fibromas develop. Dating the endometrium is identifying morphologic changes characteristic for early, middle, and late proliferative endometrium and for each of the 14 days of secretory endometrium (1, 2). Treatment of endometrial hyperplasia with the insertion of a hormone-containing intrauterine device (IUD) is an accepted method to manage endometrial hyperplasia for patients with abnormal uterine bleeding and who are unable to tolerate oral megestrol or are at high risk for complications of oral megestrol. 03 - Complex endometrial hyperplasia without. 0 to second bullet point to read “ICD-10 codes N84. 02 became effective on October 1, 2023. Code History. Department of Pathology, The Mount Sinai-NYU Medical Center, New York, New York 10029, USA. More African American women had a proliferative. beginning on Day 15 for six doses. Open in a separate window. ICD-10-CM Coding Rules. Normal location of the mediastinum changes to the right or left, depending upon the underlying cause. The uterus incidentally, is retroverted. 0-); Polyp of endometrium; Polyp of uterus NOS. Dyssynchronous endometrium, a mixture of proliferative, secretory and menstrual patterns, was seen in five specimen (3. N85. 9–9. Women with a proliferative endometrium were younger (61. The uterus incidentally, is retroverted. Common reasons for these procedures include: Abnormal (dysfunctional) uterine bleeding. Women with a proliferative endometrium were younger (61. 03 - other international versions of ICD-10 Z86. EMB showed markedly fragmented benign endometrial tissue with extensive breakdown that limited evaluation. Connect with a U. 7). Endometrial cancer begins in the layer of cells that form the lining of the uterus, called the endometrium. 9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Showing 251-275: ICD-10-CM Diagnosis Code E11. ICD-10-CM Diagnosis Code N80. erosion and ectropion of cervix without cervicitis ( N86) Use Additional. Prolonged menstruation. 02 - Endometrial intraepithelial neoplasia [EIN] The 2024 edition of ICD-10-CM N84. Hysteroscopy is now considered the standard diagnostic tool. Proliferative mucinous lesions of the endometrium: analysis of existing criteria for diagnosing carcinoma in biopsies and curettings. After menstruation, proliferative changes occur during a period of tissue regeneration. ICD-10-CM Coding Rules. 2 is applicable to female patients. National Fertility Center of Texas, Dallas 75230. Endometrial hyperplasia without atypia (as in the 2020 WHO classification) is defined as the proliferation of endometrial glands of irregular size and shape without significant cytological atypia. This is the American ICD-10-CM version of N71. Dr. The risk. ICD-10-CM Diagnosis Code C54.